MED64 System

Acquire continuous, reliable, long-term evoked and spontaneous activity across 64 channels with two-dimensional, real-time analysis of neuronal/ myocardial activity.

Features

Simultaneous recording across 64 channels

• Signals (evoked potentials and/or spontaneous activity) are acquired across an array of 64 micro-electrodes patterned on the patented MED probe.

• Any electrodes on the array (up to four) and/or external electrodes can be used for stimulation.

High S/N recording and various applications

• Because of the low-impedance of micro-electrodes (typically 7-10 k ohm at 1 kHz), signals can be acquired easily even from acute slices.

• It is well suited for experiments on acute slice as well as slice (and dissociated) cultures. It is the powerful solution for drug evaluation.

• It is possible to acquire slow-wave signals such as fEPSP or even signals from smooth muscle tissue (around 0.1 Hz) as well as high-frequency signals such as spike activities.

Low Noise and Easy-to-use

• Because of its low-impedance-electrodes, the MED64 system does not require special shielded environment. It creates high data reproducibility.

• Stimulus sites can be switched quickly and easily on the front panel of the MED64 amplifier.

• User friendly and highly sophisticated software guides you through experimental setup including stimulation parameters as well as data recording and on-line (off-line) analysis.

Long-term observation

• Dissociated cells and slice explants can be cultured directly on the MED probe.

• MED probe and connector can be placed in humidified incubator. Because of the low-impedance of electrodes, the MED64 system needs no blocking pre-amplifier required on connector.

• Responses can be recorded for days to months without any damage by planar electrodes.

Components

MED 64CH Integrated Amplifier

• Reliable, low-noise, 64 channel amplifier based on Panasonic "Technics" high fidelity audio technology

• High-bandwidth of 0.1Hz-10kHz allows users to record several types of extracellular potentials

• Samples at a max rate of 20 kHz/ch Built-in stimulator allows users to study the effects of realistic spatio-temporal stimulation patterns by programming complex induction sequences from any of the four built-in stimulation units and two external inputs

• Fast, easy switching of simulation sites

MED64 Connector

• Used for communication between the MED64 probe and amplifier

• Provides a stable platform for the MED64 probe

• Multi-layer electrical shielding rejects hum noise and provides excellent signal-to-noise ratios

• No onboard electrical circuits; connectors can be placed in high-humidity environments

MED Probes

• Biological acute or culture preparations are placed directly into the MED probe

• The MED probe allows users to stimulate and record from samples using planar microelectrodes

Several types of arrays are available:

• 8x8 (64) electrode arrays are available with four different inter-electrode spacing’s; 100, 150, 300 and 450 µm. Each patented microelectrode measures 50 µm x 50 µm - except for the 100 µm spacing configuration, with microelectrodes measuring 20 um x 20um.
• 61 electrode hexagonal arrays are available with 70 µm inter-electrode spacing. The electrodes are circular (20 µm diameter).
• Two special arrays, designed specially for simultaneously stimulating/recording from the dentate gyrus (DG), CA3 and CA1 are available for mouse (8 weeks old) and rat (16 weeks old).

• Probes come in 5 mm (for use with synchronized glass electrode recording) and 10 mm well heights

• Probes use Panasonic's Liquid Crystal Display technology

MED64 Mobius™

• MED64 Mobius™ software is the data acquisition and analysis software for the MED64 system with an abundant set of analysis functions. It is a highly-sophisticated software and suits several types of experimental needs.

• MED64 Mobius™ is available in various package including "EP measurement" and "Spike Sorter" as well as a combined package. It is flexible software consisting of various "modules". Users can design their own experimental workflow by using "Mobius editor", while they start with simple experiment quickly by using various "Mobius templates".