Prevents charge build up with a precise constant current.
Digitimer DS3 Isolated Constant Current Stimulator
Brief pulses of electricity are used in various biomedical research applications as a stimulus to excite nerve or muscle fibers. Several factors need to be considered when choosing the right stimulator.
The DS3 provides a precise Constant Current stimulus (up to 32mA) controllable in Pulse Duration and Amplitude and as with the DS2A this output comes from self-contained batteries.
The DS3 also features a “clamp” or discharge circuit which discharges the output between stimuli, preventing a charge build up on the preparation. In other constant current devices this charge build up can lead to a loss of stimulus. The DS3 can be triggered by an external device such as our new DG2A Train/Delay Generator.
NOTE: This stimulator is NOT approved for use on human subjects.
Constant Current Stimulator
- Four current ranges allow precise control of output between 2µA and 32mA.
- Output discharge (Clamp) circuit prevents capacitance build-up during stimulus trains, which is important to prevent stimulus loss.
- 90v compliance provided.
Featuring
- Accurate and reproducible stimulus characteristics.
- Switchable polarity, variable output and duration ranges (20µs to 2s).
- External pulse duration control through the BNC trigger input.
- A single-shot button, which operates irrespective of trigger inputs.
- Cases manufactured from insulating material may be rack mounted using an optional mounting frame (Model D121-11) available from Digitimer Ltd.
References – Digitimer DS3 Constant Current Stimulator
- nNOS-positive minor-branches of the dorsal penile nerves is associated with erectile function in the bilateral cavernous injury model of rats Nature Scientific Reports, Vol. 8, Article number: 929 (2018)Yen-Lin Chen, Ting-Ting Chao, Yi-No Wu, Meng-Chuan Chen, Ying-Hung Lin, Chun-Hou Liao, Chien-Chih Wu, Kuo-Chiang Chen, Shang-Shing P. Chou & Han-Sun Chiang
- spontaneous-regeneration-of-nerve-fiber-and-irreversibility-of-corporal-smooth-muscle-fibrosis-after-cavernous-nerve-crush-injury-evidence-from-serial-transmission-electron-microscopy-and-intracavern Urology, Vol. 118, August 2018, Pages 98-106Yi-No Wu, Kuo-Chiang Chen, Chun-Hou Liao, Han-Sun Chiang
- Smooth Muscle Progenitor Cells Preserve the Erectile Function by Reducing Corporal Smooth Muscle Cell Apoptosis after Bilateral Cavernous Nerve Crush Injury in Rats BioMed Research International, November 2019Yi-No Wu, Kuo-Chiang Chen, Chun-Hou Liao, Chien-Liang Liu, and Han-Sun Chiang
- Optimization of platelet‐rich plasma and its effects on the recovery of erectile function after bilateral cavernous nerve injury in a rat model Journal of Engineering and Regenerative Medicine, Aug 2013Yi‐No Wu, Chien‐Chih Wu, Ming‐Thau Sheu, Kuo‐Chiang Chen, Hsiu‐O Ho, Han‐Sun Chiang
- Neuroprotective effect of docosahexaenoic acid nanoemulsion on erectile function in a rat model of bilateral cavernous nerve injury Nature Scientific Reports Vol. 6, Article number: 33040 (2016)Chun-Hou Liao, Yi-No Wu, Bin-Huei Chen, Ying-Hung Lin, Hsiu-O Ho & Han-Sun Chiang
- Long-term administration of ketamine induces erectile dysfunction by decreasing neuronal nitric oxide synthase on cavernous nerve and increasing corporal smooth muscle cell apoptosis in rats Oncotarget. 2017 Sep 26; 8(43): 73670–73683.Hung-Sheng Shang, Yi-No Wu, Chun-Hou Liao, Tzong-Shi Chiueh, Yuh-Feng Lin, and Han-Sun Chiang
- Imaging neuronal structure dynamics using 2‐photon super‐resolution patterned excitation reconstruction microscopy Journal of Biophotonics, Vol. 11, Issue 3, March 2018Ben E. Urban, Lei Xiao, Biqin Dong, Siyu Chen, Yevgenia Kozorovitskiy, Hao F. Zhang
- DAPK and CIP2A are involved in GAS6/AXL-mediated Schwann cell proliferation in a rat model of bilateral cavernous nerve injury Oncotarget. 2018 Jan 19; 9(5): 6402–6415.Yen-Lin Chen, Yi-Ting Tsai, Ting-Ting Chao, Yi-No Wu, Meng-Chuan Chen, Ying-Hung Lin, Chun-Hou Liao, Shang-Shing P. Chou, and Han-Sun Chiang
- Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice PLOS One, journal.pone.0139332, September 2015Kang Wang, Melissa H. Kelley, Wendy W. Wu, John P. Adelman, James Maylie