Prevents charge build up with a precise constant current.
Digitimer DS3 Isolated Constant Current Stimulator
Brief pulses of electricity are used in various biomedical research applications as a stimulus to excite nerve or muscle fibers. Several factors need to be considered when choosing the right stimulator.
The DS3 provides a precise Constant Current stimulus (up to 32mA) controllable in Pulse Duration and Amplitude and as with the DS2A this output comes from self-contained batteries.
The DS3 also features a “clamp” or discharge circuit which discharges the output between stimuli, preventing a charge build up on the preparation. In other constant current devices this charge build up can lead to a loss of stimulus. The DS3 can be triggered by an external device such as our new DG2A Train/Delay Generator.
NOTE: This stimulator is NOT approved for use on human subjects.
Constant Current Stimulator
- Four current ranges allow precise control of output between 2µA and 32mA.
- Output discharge (Clamp) circuit prevents capacitance build-up during stimulus trains, which is important to prevent stimulus loss.
- 90v compliance provided.
Featuring
- Accurate and reproducible stimulus characteristics.
- Switchable polarity, variable output and duration ranges (20µs to 2s).
- External pulse duration control through the BNC trigger input.
- A single-shot button, which operates irrespective of trigger inputs.
- Cases manufactured from insulating material may be rack mounted using an optional mounting frame (Model D121-11) available from Digitimer Ltd.
References – Digitimer DS3 Constant Current Stimulator
- nNOS-positive minor-branches of the dorsal penile nerves is associated with erectile function in the bilateral cavernous injury model of rats Yen-Lin Chen, Ting-Ting Chao, Yi-No Wu, Meng-Chuan Chen, Ying-Hung Lin, Chun-Hou Liao, Chien-Chih Wu, Kuo-Chiang Chen, Shang-Shing P. Chou & Han-Sun ChiangNature Scientific Reports, Vol. 8, Article number: 929 (2018)
- spontaneous-regeneration-of-nerve-fiber-and-irreversibility-of-corporal-smooth-muscle-fibrosis-after-cavernous-nerve-crush-injury-evidence-from-serial-transmission-electron-microscopy-and-intracavern Yi-No Wu, Kuo-Chiang Chen, Chun-Hou Liao, Han-Sun ChiangUrology, Vol. 118, August 2018, Pages 98-106
- Smooth Muscle Progenitor Cells Preserve the Erectile Function by Reducing Corporal Smooth Muscle Cell Apoptosis after Bilateral Cavernous Nerve Crush Injury in Rats Yi-No Wu, Kuo-Chiang Chen, Chun-Hou Liao, Chien-Liang Liu, and Han-Sun ChiangBioMed Research International, November 2019
- Optimization of platelet‐rich plasma and its effects on the recovery of erectile function after bilateral cavernous nerve injury in a rat model Yi‐No Wu, Chien‐Chih Wu, Ming‐Thau Sheu, Kuo‐Chiang Chen, Hsiu‐O Ho, Han‐Sun ChiangJournal of Engineering and Regenerative Medicine, Aug 2013
- Neuroprotective effect of docosahexaenoic acid nanoemulsion on erectile function in a rat model of bilateral cavernous nerve injury Chun-Hou Liao, Yi-No Wu, Bin-Huei Chen, Ying-Hung Lin, Hsiu-O Ho & Han-Sun ChiangNature Scientific Reports Vol. 6, Article number: 33040 (2016)
- Long-term administration of ketamine induces erectile dysfunction by decreasing neuronal nitric oxide synthase on cavernous nerve and increasing corporal smooth muscle cell apoptosis in rats Hung-Sheng Shang, Yi-No Wu, Chun-Hou Liao, Tzong-Shi Chiueh, Yuh-Feng Lin, and Han-Sun ChiangOncotarget. 2017 Sep 26; 8(43): 73670–73683.
- Imaging neuronal structure dynamics using 2‐photon super‐resolution patterned excitation reconstruction microscopy Ben E. Urban, Lei Xiao, Biqin Dong, Siyu Chen, Yevgenia Kozorovitskiy, Hao F. ZhangJournal of Biophotonics, Vol. 11, Issue 3, March 2018
- DAPK and CIP2A are involved in GAS6/AXL-mediated Schwann cell proliferation in a rat model of bilateral cavernous nerve injury Yen-Lin Chen, Yi-Ting Tsai, Ting-Ting Chao, Yi-No Wu, Meng-Chuan Chen, Ying-Hung Lin, Chun-Hou Liao, Shang-Shing P. Chou, and Han-Sun ChiangOncotarget. 2018 Jan 19; 9(5): 6402–6415.
- Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice Kang Wang, Melissa H. Kelley, Wendy W. Wu, John P. Adelman, James MayliePLOS One, journal.pone.0139332, September 2015