BioPro Scientific – NeuLive

Multi-functional and User-friendly Electrophysiology System for Animal Studies

The NeuLive wireless system allows researchers to perform electrophysiological measurements and deliver precise electrical stimulations to the brain, heart, and muscles of commonly used preclinical research models, including mice, rats, pigs, and non-human primates.

Wireless. Lightweight. Stimulation and Recording.

In Vivo Electrophysiology

Electrophysiology plays a pivotal role in both neuroscientific and cardiovascular research. It enables researchers to explore the fundamental electrical properties of cells, including neurons and muscle cells, using invasive and non-invasive methods (EEG, ECG, EMG). These electrophysiological measurements prove valuable in tracking brain and muscle activity during various conditions such as sleep-wake cycles, seizures, Parkinson’s Disease, and treatment-induced effects.

Parkinson’s Disease Monitoring
NeuLive serves as a revolutionary tool in the realm of Parkinson’s Disease (PD) research. Its lightweight design ensures minimal discomfort for commonly used PD models including rats and mice. By integrating both wireless neural signal recording and stimulation, researchers can dynamically study PD’s neurophysiological changes and test potential interventional strategies simultaneously. Real-time monitoring brings about unparalleled insights into PD progression and therapeutic responses.

• Acute recording to increase the chance of accessing the target brain area
• Chronic recording to detect beta oscillation

Addiction
NeuLive is pivotal in addiction research, enabling real-time neural activity tracking during substance exposure. Its dual amplification and stimulation capabilities allow researchers to probe brain circuits linked to addiction and potentially modulate them, offering insights into both mechanisms and treatments. Being wireless and ultra-lightweight, NeuLive ensures animals exhibit naturalistic behaviors, making it an invaluable asset for understanding addiction’s neural underpinnings.

• Chronic recording during the conditioning and testing

Sleep/Wake Monitoring
Brain oscillation is essential for understanding the sleep pattern. With NeuLive, we are able to continuously monitor sleep activity and the effect of therapeutics on sleep patterns using both ECoG and EMG.

• Chronic 24 H continuous recording
• ECoG with spectral analysis
• Neck EMG to assist wake detection
• Detection of NREM sleep and REM sleep

In Vivo Electrical Neuromodulation

Electrical neuromodulation offers a powerful means to modulate brain activity naturally and effectively. Whether through invasive or non-invasive electrode-based approaches, programmed electrical neuromodulation can be precisely directed to specific brain regions or surface structures, making it a valuable tool for addressing a wide range of neurological disorders, pain management, and cognitive function enhancement.

Closed-loop electrical stimulation
Closed-loop electrical stimulation, when programmed to respond to pathophysiological signals or markers, represents a promising alternative to open-loop stimulation protocols. This approach triggers stimulation in a more adaptive and patient-specific manner. Notably, the application of closed-loop stimulation has demonstrated significant efficacy in the treatment of patients with Parkinson’s Disease.

Temporal interference stimulation
Temporal interference stimulation is an innovative neurostimulation technique that offers significant advantages. It excels in precision, allowing for targeted modulation of specific brain regions by applying multiple electric fields with slightly different frequencies. This non-invasive approach makes it particularly valuable for treatments requiring deep brain stimulation without invasive procedures.

Sine wave/Pulse stimulation
Sine wave and pulse stimulation methods are versatile and widely applied forms of electrical stimulation. They offer flexibility for various medical and research purposes.