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Cool Solutions Heat/Cooled Temperature Control System

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Cool Solutions Heat/Cooled Temperature Control System


Heat/Cooled Temperature Control System


Cool Solutions CS-1 Peltier Thermal Stimulus Delivery System

  • Heat from 20 to 50°C in 3 seconds, then cool to 2°C in just a few more seconds — all controlled by your electrophysiology software
  • Display Peltier, heatsink or bath temperature
  • Set the desired temperature from the front panel or from your computer: The CS-1 can generate any desired timecourse of temperature change, by simply converting a voltage from your interface into a temperature
  • Optically isolated bath sensor for low noise
  • Suitable for single channel (no detectable noise added), whole cell patch clamping, or fluorescent ion imaging of groups of cells
  • Optional water cooling for low-temperature work
  • Two output BNCs to monitor and record two temperatures externally (e.g. Peltier and bath)
  • All components included – five minute setup
  • Tried and tested design, used in major thermoTRP labs for over a decade (publication list)

Peltier Heating/Cooling Element

Superfuse small areas (e.g. groups of cells) in a recording bath at a precise, controlled, and rapidly adjustable local temperature. This system has been specifically developed for patch clamp experiments to apply thermal stimuli without introducing noise or interference. It is also suitable for intracellular ion imaging in cultured cells or tissue slices, oocyte recording, intracellular microelectrode recording, or extracellular (e.g. brain slice) recording.

Cool Solutions Heating Element

Cool Solutions Peltier
Effect of flow rate on the static temperature and on the rate of temperature change.

(A) Static temperature at the Peltier element (circles), in the solution leaving the Peltier element (squares), and at the cell (triangles) at flow rates between 0.6 and 1.7 ml/ min. Command temperatures were 50°C and 0°C, and feedback was from the Peltier element.

(B) Temperature at the cell during step temperature commands at flow rates of 0.6, 1.0 and 1.7 ml/min. The initial temperature at the heating/cooling chamber was 32°C and the command temperature was stepped to 0°C for 30 s, then back to 32°C.

Reid, et al, J Neuroscience Methods, 2001

Your thermoTRP channels won’t know what hit them.

November 2014:  “My lab has been using the Cool Solutions device for over ten years, and it has been a fantastic unit for characterizing the properties of thermosensitive TRP channels, both native and cloned. Its Peltier cooling and heating provide accurate and quiet thermal stimuli in our electrophysiology and imaging experiments, with superior range, speed, and reliability.”

Dr. David Julius
Nobel Prize in Physiology or Medicine 2021

Department of Physiology
University of California, San Francisco

Cool Solutions Peltier

The main controller is ready for 19″ rack mounting (size 2U).

483mm w x 90mm h x 395mm deep 19″ w x 3.5″ tall x 15.5″ deep 6.5 kg = 14 lbs.

Cool Solutions Peltier

Three externally amplified temperature sensors including an optically isolated bath sensor, for virtually noise-free operation.

Cool Solutions Peltier

12V batteries and charger included for noise-free heating and cooling.

Cool Solutions Peltier

Special 0.1°C error thermocouple for exceptional accuracy.

Cool Solutions Peltier

References – Cool Solutions

Additional information

Weight 26 lbs