High-speed solution switcher.
Fast Piezo Solution Switcher
The piezo solution switcher uses a high-speed piezo flexure guided nanopositioner to move pipette tips in solution switching applications. It can move an electrode tip across a 5 µm thick theta glass septum. This system is ideal for measuring cellular response to drugs or other elements in solution.
Piezo movement can be triggered by either input from common recording amplifier equipment or by Siskiyou software via a LabVIEW™ interface that can control distance, frequency and dwell time. The piezo also includes the piezo amplifier box and the Input-Shaping® board, which significantly reduces pipette tip vibration and can be programmed to virtually eliminate resonances from your specific system.
The piezo flexure guided nanopositioner is mounted to our ultra-stable MX1640 crossed roller micromanipulator. The MX1640 has 20mm of travel in all four axes. The fourth axis can be set at any angle to select the desired approach angle. This adjustable fourth axis incorporates our MXC-45 to allow rotation of the piezo/pipette assembly up and out of the experiment for easy glass replacement. The base of the MX1640 also has a built-in coarse adjustment for rotation of the entire manipulator, or can also be used with our MX-RS rotation stage for more precise motion.
References – Fast Perfusion Solution Switcher
- The Neuroprotective Role of Origanum syriacum L. and Lavandula dentata L. Essential Oils through Their Effects on AMPA Receptors BioMed Research International, Vol. 2019, Article ID 5640173Mohammad Qneibi, Nidal Jaradat, Mohammed Hawash, Abdel Naser Zaid, Abdel-Razzak Natsheh, Remah Yousef, and Qais AbuHasan
- The inhibitory role of curcumin derivatives on AMPA receptor subunits and their effect on the gating biophysical properties European Journal of Pharmaceutical Sciences, Vol. 136, August 2019Mohammad Qneibi, Othman Hamed, Oswa Fares, Nidal Jaradat, Abdel-Razzak Natsheh, Qais Abu Hasan, Nour Emwas, Rana Al-Kerm, Rola Al-Kerm
- Subtype-specific control of P2X receptor channel signaling by ATP and Mg2+ Proc. Natl. Acad. Sci. USA. 2013; 110:E3455-E3463.Mufeng Li, Shai D. Silberberg, and Kenton J. Swartzu
- Ortho versus Meta Chlorophenyl-2,3-Benzodiazepine Analogues: Synthesis, Molecular Modeling, and Biological Activity as AMPAR Antagonists American Chemical Society, Omega 2020, February 2020Mohammad Qneibi, Nidal Jaradat, Mohammed Hawash, Abdurrahman Olgac, and Nour Emwas
- Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP eLife 8:e47060, 2019Mufeng Li, Yao Wang, Rahul Banerjee, Fabrizio Marinelli, Shai Silberberg, Jose´ D Faraldo-Gomez, Motoyuki Hattori, Kenton Jon Swartz
- Inhibition and assessment of the biophysical gating properties of GluA2 and GluA2/A3 AMPA receptors using curcumin derivatives Journals.plos.org, August 2019Mohammad Qneibi ,Othman Hamed,Abdel-Razzak Natsheh,Oswa Fares,Nidal Jaradat,Nour Emwas,Qais AbuHasan,Rana Al-Kerm,Rola Al-Kerm
- Effect of Geraniol and Citronellol Essential Oils on the Biophysical Gating Properties of AMPA Receptors Applied Sciences, November 2019Mohammad Qneibi, Nidal Jaradat, Nour Emwas